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Stem cells, mitochondria and aging.
Ahlqvist KJ, Suomalainen A, Hämäläinen RH. Ahlqvist KJ, et al. Biochim Biophys Acta. 2015 Nov;1847(11):1380-6. doi: 10.1016/j.bbabio.2015.05.014. Epub 2015 May 23. Biochim Biophys Acta. 2015. PMID: 26014347 Free article. Review.
Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias.
Hämäläinen RH, Landoni JC, Ahlqvist KJ, Goffart S, Ryytty S, Rahman MO, Brilhante V, Icay K, Hautaniemi S, Wang L, Laiho M, Suomalainen A. Hämäläinen RH, et al. Among authors: ahlqvist kj. Nat Metab. 2019 Oct;1(10):958-965. doi: 10.1038/s42255-019-0120-1. Epub 2019 Oct 7. Nat Metab. 2019. PMID: 32694840
Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice.
Ahlqvist KJ, Hämäläinen RH, Yatsuga S, Uutela M, Terzioglu M, Götz A, Forsström S, Salven P, Angers-Loustau A, Kopra OH, Tyynismaa H, Larsson NG, Wartiovaara K, Prolla T, Trifunovic A, Suomalainen A. Ahlqvist KJ, et al. Cell Metab. 2012 Jan 4;15(1):100-9. doi: 10.1016/j.cmet.2011.11.012. Cell Metab. 2012. PMID: 22225879 Free article.